dr hab. prof. UP Ewa Żesławska
2023
Nitek W., E. Szymańska E., Tejchman W., Żesławska E. Architecture of the rings of 5-arylidenerhodanine derivatives versus P-gp inhibition. 2023. Acta Crystallographica Section C, 79, 334-343.
https://doi.org/10.1107/S2053229623006502
Czarnota-Łydka K., Sudoł-Tałaj S., Kucwaj-Brysz K., Kurczab R., Satała G., de Candia M., Samarelli F., Altomare C.D., Carocci A., Barbarossa A., Żesławska E., Głuch-Lutwin M., Mordyl B., Kubacka M., Wilczyńska-Zawal N., Jastrzębska-Więsek M., Partyka A., Khan N., Więcek M., Nitek W., Honkisz-Orzechowska E., Latacz G., Wesołowska A., Carrieri A., Handzlik J. 2023. Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer’s disease. European Journal of Medicinal Chemistry 5, 259, 115695.
https://doi.org/10.1016/j.ejmech.2023.115695
Sudoł-Tałaj S., Kucwaj-Brysz K., Podlewska S., Kurczab R., Satała G., Mordyl B., Głuch-Lutwin M., Wilczyńska-Zawal N., Jastrzębska-Więsek M., Czarnota-Łydka K., Kurowska K., Kubacka M., Żesławska E., Nitek W., Olejarz-Maciej A., Doroz-Płonka A., Partyka A., Latacz G., Wesołowska A., Handzlik J. 2023. Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer’s disease for potent serotonin 5-HT6R agents. European Journal of Medicinal Chemistry 24, 260, 115756.
https://doi.org/10.1016/j.ejmech.2023.115756
Łażewska D., Więcek M., Satała G., Chałupnik P., Żesławska E., Honkisz-Orzechowska E., Tarasek M., Latacz G., Nitek W., Szymańska E., Handzlik J. 2023. New Triazine Derivatives as Serotonin 5-HT6 Receptor Ligands. Molecules 28, 1108.
https://doi.org/10.3390/molecules28031108
Mazur G., Pańczyk-Straszak K., Rapacz A., Kiszela J., Smolik M., Gawlik M., Walczak M., Czekajewska J., Poloczek C., Karczewska E., Żesławska E., Nitek W., Niedbał A., Leśniak J., Ciapala K., Pawlik K., Mika J., Waszkielewicz A.M. 2023. Promising anticonvulsant and/or analgesic compounds among 5-chloro-2- or 5-chloro-4-methyl derivatives of xanthone coupled to aminoalkanol moieties—Design, synthesis and pharmacological evaluation. Chemical Biology and Drug Design 101, 278-325.
https://doi.org/10.1111/cbdd.14102
2022
Żesławska E., Tejchman W., Kincses A., Spengler G., Nitek W., Żuchowski G., Szymańska E. 2022. „5-Arylidenerhodanines as P-gp Modulators: An Interesting Effect of the Carboxyl Group on ABCB1 Function in Multidrug-Resistant Cancer Cells”. International Journal of Molecular Sciences 23, 18: 10812.
https://doi.org/10.3390/ijms231810812
Wesam A., Garbo S., Kincses A., Nové M., Spengler G., Di Bello E., Honkisz-Orzechowska E., Karcz T., Szymańska E., Żesławska E., Starek M., Dąbrowska M., Nitek W., Kucwaj-Brysz K., Pyka P., Fioravanti R., Jacob C., Battistelli C., Zwergel K., Handzlik J. 2022. Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma. European Journal of Medicinal Chemistry 243, 114761.
https://doi.org/10.1016/j.ejmech.2022.114761
Żesławska E., Zakrzewski R., Nowicki A., Korona-Głowniak I., Lyčka A., Kania A., Zborowski K.K., Suder P., Skórska-Stania A., Tejchman W. Synthesis, Crystal Structures, Lipophilic Properties and Antimicrobial Activity of 5-Pyridylmethylidene-3-rhodaninecarboxyalkyl Acids Derivatives. Molecules 2022, 27, 3975.
https://doi.org/10.3390/molecules27133975
Tejchman W., Kołodziej P., Kalinowska-Tłuścik J., Nitek W., Żuchowski G., Bogucka-Kocka A., Żesławska E. 2022. Discovery of Cinnamylidene Derivative of Rhodanine with High Anthelmintic Activity against Rhabditis sp. Molecules 27, 2155.
https://doi.org/10.3390/molecules27072155
Kucwaj-Brysz K., Ali W., Kurczab R., Sudoł-Tałaj S., Wilczyńska-Zawal N., Jastrzębska-Więsek M., Satała G., Mordyl B., Żesławska E., Olejarz-Maciej A., Czarnota K., Latacz G., Partyka A., Wesołowska A., Nitek W., Handzlik J. 2022. An exit beyond the pharmacophore model for 5-HT6R agents – a new strategy to gain dual 5-HT6/5-HT2A action for triazine derivatives with procognitive potential. Bioorganic Chemistry 121, 105695.
https://doi.org/10.1016/j.bioorg.2022.105695
Nitek W., Kania A., Marona H., Waszkielewicz A.M., Żesławska E. 2022. Influence of protonation on the geometry of 2-{[(2,6-dimethylphenoxy)ethyl]amino}-1-phenylethan-1-ol: crystal structures of the free base and of its chloride and 3-hydroxybenzoate salt forms. Acta Crystallographica Section C 78.
https://doi.org/10.1107/S2053229621012614
2019-2021
Żesławska E., Szymańska E., Nitek W., Handzlik J. 2021. Crystallographic studies of piperazine derivatives of 3-methyl-5-spirofluorenehydantoin in search of structural features of P-gp inhibitors. Acta Crystallographica C77, 467-478.
https://doi.org/10.1107/S2053229621006756
Korona-Głowniak I., Nitek W., Tejchman W., Żesławska E. 2021. Influence of chlorine and methyl substituents and their position on the antimicrobial activities and crystal structures of 4-methyl-1,6-diphenylpyrimidine-2(1H)-selenone derivatives. Acta Crystallographica C77, 649-658.
https://doi.org/10.1107/S205322962100975X
Żesławska E., Kucwaj-Brysz K., Kincses A., Spengler G., Szymańska E., Czopek A., Marć M.A., Kaczor A., Nitek W., Domínguez-Álvarez E., Latacz G., Kieć-Kononowicz K., Handzlik J. 2021. An insight into the structure of 5-spiro aromatic derivatives of imidazolidine-2,4-dione, a new group of very potent inhibitors of tumor multidrug resistance in T-lymphoma cells. Bioorganic Chemistry 109: 104735.
https://doi.org/10.1016/j.bioorg.2021.104735
Kaczor A., Witek K., Podlewska S., Sinou V., Czekajewska J., Żesławska E., Doroz-Płonka A., Lubelska A., Latacz G., Nitek W., Bischoff M., Alibert S., Pagès J-M., Jacob C., Karczewska E., Bolla J-M., Handzlik J. 2021. Molecular Insights into an Antibiotic Enhancer Action of New Morpholine-Containing 5-Arylideneimidazolones in the Fight against MDR Bacteria. International Journal of Molecular Sciences 22, 2062.
https://doi.org/10.3390/ijms22042062
Kucwaj-Brysz K., Latacz G., Podlewska S., Żesławska E., Handzlik J., Lubelska A., Satała G., Nitek W., Handzlik J. 2021. The relationship between stereochemical and both, pharmacological and ADME-Tox, properties of the potent hydantoin 5-HT7R antagonist MF-8. Bioorganic Chemistry 106: 104466.
https://doi.org/10.1016/j.bioorg.2020.104466
Witek K., Latacz G., Kaczor A., Czekajewska J., Żesławska E., Chudzik A., Karczewska E., Nitek W., Kieć-Kononowicz K., Handzlik J. 2020. Phenylpiperazine 5,5-Dimethylhydantoin Derivatives as First Synthetic Inhibitors of Msr(A) Efflux Pump in Staphylococcus epidermidis. Molecules 25, 3788.
https://doi.org/10.3390/molecules25173788
Sudoł S., Kucwaj-Brysz K., Kurczab R., Wilczyńska N., Jastrzębska-Więsek M., Satała G., Latacz G., Głuch-Lutwin M., Mordyl B., Żesławska E., Nitek W., Partyka A., Buzun K., Doroz-Płonka A., Wesołowska A., Bielawska A., Handzlik J. 2020. Chlorine substituents and linker topology as factors of 5-HT6R activity for novel highly active 1,3,5-triazine derivatives with procognitive properties in vivo. European Journal of Medicinal Chemistry 203, 112529.
https://doi.org/10.1016/j.ejmech.2020.112529
Nitek W., Kania A., Marona H., Waszkielewicz A.M., Żesławska E. 2020. The conformational analyses of 2‐amino‐N‐[2‐(dimethylphenoxy)ethyl]propan‐1‐ol derivatives in different environments. Acta Crystallographica Section C 76: 681-689
https://doi.org/10.1107/S2053229620008244
Gunia-Krzyżak A., Żesławska E., Słoczyńska K., Żelaszczyk D., Sowa A., Koczurkiewicz-Adamczyk P., Popiół J., Nitek W., Pękala E., Marona H. 2020. S(+)-(2E)-N-(2-Hydroxypropyl)-3-Phenylprop-2-Enamide (KM-568): A Novel Cinnamamide Derivative with Anticonvulsant Activity in Animal Models of Seizures and Epilepsy. International Journal of Molecular Sciences 21: 4372
https://doi.org/10.3390/ijms21124372
Tejchman W., Korona-Glowniak I., Kwietniewski L., Żesławska E., Nitek W., Suder P., Żylewski M., Malm A. 2020. Antibacterial properties of 5-substituted derivatives of rhodanine-3-carboxyalkyl acids. Part II. Saudi Pharmaceutical Journal 28: 414–426
https://doi.org/10.1016/j.jsps.2020.02.002
Żesławska E., Korona-Głowniak I., Nitek W., Tejchman W. 2020. Effect of the position of a methoxy substituent on the antimicrobial activity and crystal structures of 4-methyl-1,6-diphenylpyrimidine-2(1H)-selenone derivatives. Acta Crystallographica Section C 76: 359-366
https://doi.org/10.1107/S2053229620004040
Żesławska E., Kalinowska-Tłuścik J., Nitek., Marona H., Waszkielewicz A.M. 2020. Influence of the position of the methyl substituent and N-oxide formation on the geometry and intermolecular interactions of 1-(phenoxyethyl)piperidin-4-ol derivatives. Acta Crystallographica Section C 76:30-36.
https://doi.org/10.1107/S2053229619015948
Żesławska E., Kincses A., Spengler G., Nitek W., Tejchman W., Handzlik J. 2019. Pharmacophoric features for a very potent 5 -spirofluorenehydantoin inhibitor of cancer efflux pump ABCB1, based on X -ray analysis. Chemical Biology & Drug Design 93 (5).
https://doi.org/10.1111/cbdd.13473
Kaczor A., Witek K., Podlewska S., Czekajewska J., Lubelska A., Żesławska E., Nitek W., Latacz G., Alibert S., Pagès J.-M., Karczewska E., Kieć-Kononowicz K., Handzlik J. 2019. 5-Arylideneimidazolones with amine at position 3 as potential antibiotic adjuvants against multidrug resistance bacteria. Molecules 24:438.
https://doi.org/10.3390/molecules24030438
Nasim M.J., Witek K., Kinces A., Abdin A.J., Żesławska E., Marć M.A., Gajdacs M., Spengler G., Nitek W., Latacz G., Karczewska E., Kieć-Kononowicz K., Handzlik J., Jacob C. 2019. Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria. New Journal of Chemistry 43(15):6021-6031.
https://doi.org/10.1039/c9nj00563c
Popiół J., Gunia-Krzyżak A., Piska K., Żelaszczyk D., Koczurkiewicz P., Słoczyńska K., Wójcik-Pszczoła K, Krupa A., Kryczyk-Poprawa A., Żesławska E., Nitek W., Żmudzki P., Marona H., Pękala E. 2019. Discovery of Novel UV-Filters with Favorable Safety Profiles in the 5-Arylideneimidazolidine-2,4-dione Derivatives Group. Molecules 24:2321.
https://doi.org/10.3390/molecules24122321
Pańczyk K., Pytka K., Jakubczyk M., Rapacz A., Siwek A., Głuch-Litwin M., Gryboś A., Słoczyńska K., Koczurkiewicz P., Ryszawy D., Pękala E., Budziszewska B., Starek-Świechowicz B., Suraj-Prażmowska J., Walczak M., Żesławska E., Nitek W., Bucki A., Kołaczkowski M., Żelaszczyk D., Francik R., Marona H., Waszkielewicz A.M. 2019. Synthesis of N-(phenoxyalkyl)-, N-{2-[2-(phenoxy)ethoxy]ethyl}- or N-(phenoxyacetyl)piperazine Derivatives and Their Activity Within the Central Nervous. Chemistry Select 4(32):9381-9393.
https://doi.org/10.1002/slct.201902648
Tejchman W., Orwat B., Korona-Głowniak I., Barbasz A., Kownacki I., Latacz G., Handzlik J., Żesławska E., Malm A. 2019. Highly efficient microwave synthesis of rhodanine and 2-thiohydantoin derivatives and determination of relationships between their chemical structures and antibacterial activity. RSC Advances 67: 39367–39380.
https://doi.org/10.1039/c9ra08690k
2017-2018
Kucwaj-Brysz K., Kurczab R., Jastrzębska-Więsek M., Żesławska E., Satała G., Nitek W., Partyka A., Siwek A., Jankowska A., Wesołowska A., Kieć-Kononowicz K., Handzlik J. 2018. The computer-aided insight into the receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT7 receptor agents with antidepressant activity. European Journal of Medicinal Chemistry 147:102-114.
https://doi.org/10.1016/j.ejmech.2018.01.093
Kucwaj-Brysz K., Kurczab R., Żesławska E., Lubelska A., Marć M.A., Latacz G., Satała G., Nitek W., Kieć-Kononowicz K., Handzlik J. 2018. The role of aryl-topology in balancing between selective and dua 5-HT7R/5-HT1A actions of 3,5-substituted hydantoins. Med Chem Comm 9:1033-1044.
https://doi.org/10.1039/c8md00168e
Żesławska E., Nitek W., Marona H., Waszkielewicz A.M. 2018. Supramolecular architectures of succinates of 1-hydroxypropan-2-aminium derivatives. Acta Crystallographica Section C 74:856-862.
https://doi.org/10.1107/S2053229618008574
Pańczyk K., Żelaszczyk D., Koczurkiewicz P., Słoczyńska K., Pękala E., Żesławska E., Nitek W., Żmudzki P., Marona H., Waszkielewicz A. 2018. Synthesis and anticonvulsant activity of phenoxyacetyl derivatives of amines, including aminoalkanols and amino acids. Med Chem Comm 9:1933-1948.
https://doi.org/10.1039/c8md00430g
Żesławska E., Nitek W., Marona H., Gunia-Krzyżak A. 2018. Cinnamamide pharmacophore for anticonvulsant activity: evidence from crystallographic studies. Acta Crystallographica Section C 74:782-788.
https://doi.org/10.1107/S2053229618007660
Żesławska E., Nitek W., Tejchman W., Handzlik J. 2018. Influence of 3-[5-(4′-N,N-diethylaminobenzylidene)-rhodanine]-propionic acid on conformation of the 5-(4-chlorobenzylidene)-2-(4-methylpiperazin-1-yl)-3,5-dihydroimidazol-4-one. Acta Crystallographica Section C 74:1427-1433.
https://doi.org/10.1107/S2053229618013980
Żesławska E., Kincses A., Unger V., Toth V., Spengler G., Nitek W., Tejchman W. 2018. Exocyclic sulfur and selenoorganic compounds towards their anticancer effects: crystallographic and biological studies. Anticancer Research 38(8): 4577-4584.
https://doi.org/10.21873/anticanres.12762
Żesławska E., Nitek W., Marona H., Gunia-Krzyżak A. 2017. Crystallographic studies of cinnamamide derivatives as means of searching for anticonvulsant activity. Acta Crystallographica Section C 73: 953-959.
https://doi.org/10.1107/S2053229617013845
Gunia-Krzyżak A., Żesławska E., Bareyre F.M., Nitek W., Waszkielewicz A.M., Marona H. 2017. Physicochemical and biological evaluation of a cinnamamide derivative R,S-(2E)-1-(3-hydroxypiperidin-1-yl)-3-phenylprop-2-en-1-one (KM-608) for nervous system disorders. Chemical Biology & Drug Design 90:244-253.
https://doi.org/10.1111/cbdd.12943
Żesławska E., Nitek W., Handzlik J. 2017. Conformational study of the (Z)-5-(4-chlorobenzylidene)-2-[4-(2-hydroxyethyl)piperazin-1-yl]-3H-imidazol-4(5H)-one in different environments: insight into the structural properties of bacterial efflux pump inhibitors. Acta Crystallographica Section C 73:1151-1157.
https://doi.org/10.1107/S2053229617016461
Żesławska E., Korona-Głowniak I., Szczesio M., Olczak A., Żylewska A, Tejchman W., Malm A. 2017. Structural analysis and antimicrobial activity of 2[1H]-pyrimidinethione/selenone derivatives. Journal of Molecular Structure 1142: 261-266.
https://doi.org/10.1016/j.molstruc.2017.04.067
Żesławska E., Jakubowska A., Nitek W. 2017. Conformational study of the 3,6-dihydro-2H-1,4-oxazin-2-one fragment in 8-tert-butyl-7-methoxy-8-methyl-9-oxa-6-azaspiro[4.5]decane-2,10-dione stereoisomers. Acta Crystallographica Section C 73:556-562.
https://doi.org/10.1107/S2053229617009068
Gunia-Krzyżak A., Żelaszczyk D., Rapacz A., Żesławska E., Waszkielewicz A.M., Pańczyk K., Słoczyńska K., Pękala E., Nitek W., Filipek B.Marona H. 2017. Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH3 or 2-CH3. Bioorganic & Medicinal Chemistry 25: 471-482.
https://doi.org/10.1016/j.bmc.2016.11.014
Stawoska I., Tejchman W., Mazuryk O., Lyčka A., Nowak-Sliwinska P., Żesławska E., Nitek W., Kania A. 2017. Spectral characteristic and preliminary anticancer activity in vitro of selected rhodanine-3-carboxylic acids derivatives. Journal of Heterocyclic Chemistry 54: 2889-2897.
https://doi.org/10.1002/jhet.2897
Rendeková J., Vlasáková D., Arsenyan P., Vasiljeva J., Nasim M.J., Witek K., Domínguez-Álvarezc E., Żesławska E., Mániková D., Tejchman W., Saleem R.S.Z., Rory K., Handzlik J., Chovanec M. 2017. The Selenium-Nitrogen Bond as Basis for Reactive Selenium Species with Pronounced Antimicrobial Activity. Current Organic Synthesis 14(8): 1082-1090.
